The U.S. Department of the Treasury's Office of Foreign Assets Control issued new guidance indicating that the United States has placed sanctions on Cuban President Miguel Diaz-Canel, his wife and former President Raul Castro's son and one of his grandsons, Bloomberg reported on June 4. The announcement also indicated the imposition of sanctions on multiple Cuban government bodies and a mining sector body, Minera La Victoria, a joint venture project between Australia-based Antilles Gold Ltd. and Cuban GeoMinera SA.

Also on June 4, U.S. Secretary of State Marco Rubio posted on X that the United States is targeting the network that "enables and funds Cuba's subversive and radical operations." He also said, "Anyone providing services to these sanctioned actors is at risk of sanctions themselves. Foreign banks and other companies that provide services to these entities should freeze those activities." Raul Guillermo Rodriguez Castro (also known as Raulito) was not included in the sanctions list; Raulito has been one of the main Cuban government members engaged in talks with the United States.